I have never been audited and don't want to be, but I work out of my home and have expenses associated with that. I don't see why not take legitimate deductions.
If you genuinely use a room in your office, it shouldn't be a problem to claim it. If you take a trip to Hawaii for the purpose of taking stock photos, then it seems like it should be deductible. If you take a trip to Hawaii for your anniversary and take a few snaps along the way, maybe not a good idea to deduct it.