As Steve said, owning the artwork doesn't make you the copyrightholder. And with replacing artwork with my own photos in an image I'm uploading (which I've done) I've typically had to upload a property release for that "art" as agencies will reject, assuming the images belong to someone else.
"Art" is pretty broad - I use my own release for some handpainted easter eggs that I made as props too. Agencies are getting much more careful about property releases.